Treating Clostridium difficile infection with fecal microbiota transplantation.

Johan S Bakken, Thomas Borody, Lawrence J Brandt, Joel V Brill, Daniel C Demarco, Marc Alaric Franzos, Colleen Kelly, Alexander Khoruts, Thomas Louie, Lawrence P Martinelli, Thomas A Moore, George Russell, Christina Surawicz

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2012;9(12):1044-9

PMID: 21871249

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Abstract

Clostridium difficile infection is increasing in incidence, severity, and mortality. Treatment options are limited and appear to be losing efficacy. Recurrent disease is especially challenging; extended treatment with oral vancomycin is becoming increasingly common but is expensive. Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured. We discuss the rationale, methods, and use of fecal microbiota transplantation.

Address: St Luke's Infectious Disease Associates, Duluth, Minnesota, USA.

DOI: 10.1016/j.cgh.2011.08.014

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MeSH Terms: Clostridioides difficile, Clostridium Infections, Feces, Humans, Probiotics, Treatment Outcome