Mechanism for sulfur acquisition by the alkanesulfonate monooxygenase system.

Holly R Ellis

Journal: Bioorganic chemistry 2012;39(5-6):178-84

PMID: 21880344

Full Text on Elsevier Science View on PubMed

Abstract

The bacterial alkanesulfonate monooxygenase system is involved in the acquisition of sulfur from organosulfonated compounds during limiting sulfur conditions. The reaction relies on an FMN reductase to supply reduced flavin to the monooxygenase enzyme. The reaction catalyzed by the alkanesulfonate monooxygenase enzyme involves the carbon-sulfur bond cleavage of a wide range of organosulfonated compounds. A C4a-(hydro)peroxyflavin is the oxygenating intermediate in the mechanism of desulfonation by the alkanesulfonate monooxygenase. This review discusses the physiological importance of this system, and the individual kinetic parameters and mechanistic properties of this enzyme system.

Address: The Department of Chemistry and Biochemistry, Auburn University, AL 36849, United States. [email protected]

DOI: 10.1016/j.bioorg.2011.08.001