Signaling the glycoshield: maintenance of the Candida albicans cell wall.

Jesús Pla, Joachim F Ernst

Journal: International journal of medical microbiology : IJMM 2011;301(5):378-83

PMID: 21555242

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Abstract

In fungi, the cell wall is a scaffold, an armor and an environmental gate. Sugar polymers including protein-O- or N-linked glycosyl chains or polysaccharides such as glucan or chitin are essential components to maintain cell wall functions. We describe mechanisms in the human fungal pathogen Candida albicans, by which the integrity of glycostructures are sensed and regulated. The results stress the importance of membrane sensors and MAP kinase pathways in the maintenance of cell wall structure and function.

Address: Institut für Mikrobiologie, Molekulare Mykologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1/26.12, 40225 Düsseldorf, Germany. [email protected]

DOI: 10.1016/j.ijmm.2011.04.003

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MeSH Terms: Candida albicans, Cell Wall, Glycosylation, Humans, Signal Transduction