Research in practice: Antimicrobial peptides of the skin.

Regine Gläser

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2012;9(9):678-80

PMID: 21615686

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Abstract

Antimicrobial peptides represent evolutionary ancient molecules whose importance became evident within the last years. These highly effective peptides protect the skin and other epithelia against infection and form a fast acting "chemical barrier" also regulating the normal flora of the skin and mucosa. In the Department of Dermatology, University Hospital Kiel, various antimicrobial peptides have been discovered, characterized and investigated in healthy persons as well as in different skin diseases. Everyday clinical observations formed the background for several interesting hypotheses and findings.

Address: Department of Dermatology, Venereology and Allergy, University Clinic Schleswig-Holstein, Campus Kiel, Germany. [email protected]

DOI: 10.1111/j.1610-0387.2011.07708.x

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MeSH Terms: Antimicrobial Cationic Peptides, Dermatitis, Atopic, Escherichia coli, Humans, Immunity, Innate, S100 Calcium Binding Protein A7, S100 Proteins, Skin, Skin Care, Skin Diseases, Skin Diseases, Infectious, Staphylococcus epidermidis, Ultraviolet Rays