Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis.

Jorg Dietrich, Michelle Monje

Journal: Behavioural brain research 2012;227(2):376-9

PMID: 21621557

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Abstract

Cancer therapies frequently result in a spectrum of neurocognitive deficits that include impaired learning, memory, attention and speed of information processing. Damage to dynamic neural progenitor cell populations in the brain are emerging as important etiologic factors. Radiation and chemotherapy-induced damage to neural progenitor populations responsible for adult hippocampal neurogenesis and for maintenance of subcortical white matter integrity are now believed to play major roles in the neurocognitive impairment many cancer survivors experience.

Address: Department of Neurology, Division of Child Neurology, Stanford University Medical Center, 750 Welch Road, Suite 317, Palo Alto, CA 94304, USA. [email protected]

DOI: 10.1016/j.bbr.2011.05.012

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MeSH Terms: Antineoplastic Agents, Cognition, Cognition Disorders, Hippocampus, Humans, Neoplasms, Neural Stem Cells, Neurogenesis, Neurons