Effects of coenzyme Q10 on salivary secretion.

Koufuchi Ryo, Atsuko Ito, Rie Takatori, Yoshinori Tai, Kazumune Arikawa, Taro Seido, Takashi Yamada, Keiko Shinpo, Yoh Tamaki, Kenji Fujii, Yorihiro Yamamoto, Ichiro Saito

Journal: Clinical biochemistry 2011;44(8-9):669-74

PMID: 21406193

Full Text on Elsevier Science View on PubMed

Abstract

OBJECTIVES

Dry mouth is a condition associated with reduced salivary secretion and is thought to be related to aging. This study was conducted to test whether reduced (ubiquinol) or oxidized (ubiquinone) forms of CoQ10 affect salivary secretion and salivary CoQ10 content before and after treatment.

DESIGN AND METHODS

Sixty-six patients were given either ubiquinol or ubiquinone orally at a dosage of 100 mg/day, or a placebo for 1 month, and salivary secretion and salivary CoQ10 content were analyzed before and after treatment.

RESULTS

Both parameters were significantly improved following treatment with either form of CoQ10, suggesting the effectiveness of CoQ10 in attenuating dry mouth symptoms.

CONCLUSION

CoQ10 was locally detected in salivary glands, suggesting that orally administered CoQ10 was transported to the salivary glands via the blood stream and exerted its activity, improving salivary secretion.

Address: Department of Pathology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.

DOI: 10.1016/j.clinbiochem.2011.03.029

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MeSH Terms: Administration, Oral, Aged, Antioxidants, Female, Humans, Male, Middle Aged, Salivation, Ubiquinone