Transient dyslipidemia mimicking the plasma lipid profile of Tangier disease in a diabetic patient with gram negative sepsis.

Carlos Palacio, Irene Alexandraki, Roger L Bertholf, Arshag D Mooradian

Journal: Annals of clinical and laboratory science 2012;41(2):150-3

PMID: 21844573

Abstract

Tangier disease is a rare genetic disorder of lipid metabolism characterized by low concentrations of plasma high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol with normal or elevated levels of triglycerides. In this case report we describe a patient with diabetes who experienced an episode of urosepsis with a plasma lipid profile resembling Tangier disease. Experimental evidence in the literature suggests that similar lipid changes may occur due to cytokines released during sepsis. Clinicians should be aware of these changes to avoid misdiagnosis of lipid disorders.

Address: Department of Medicine, University of Florida, 653-1 West Eighth Street, Jacksonville, FL 32209, USA. [email protected]

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MeSH Terms: Bacteremia, Cholesterol, HDL, Cholesterol, LDL, Diabetes Complications, Diabetes Mellitus, Dyslipidemias, Escherichia coli, Female, Humans, Middle Aged, Tangier Disease, Triglycerides