MADOR: a new tool to calculate decrease of effective doses in human after DTPA therapy.

P Fritsch, O Grémy, C Hurtgen, P Bérard, L Grappin, J L Poncy

Journal: Radiation protection dosimetry 2011;144(1-4):371-5

PMID: 21131659

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Abstract

Abstract models have been developed to describe dissolution of Pu/Am/Cm after internal contamination by inhalation or wound, chelation of actinides by diethylene triamine penta acetic acid (DTPA) in different retention compartments and excretion of actinide-DTPA complexes. After coupling these models with those currently used for dose calculation, the modelling approach was assessed by fitting human data available in IDEAS database. Good fits were obtained for most studied cases, but further experimental studies are needed to validate some modelling hypotheses as well as the range of parameter values. From these first results, radioprotection tools are being developed: MAnagement of DOse Reduction after DTPA therapy.

Address: Laboratoire de Radiotoxicologie, CEA/DSV/iRCM/SREIT, BP 12, F-91680 Bruyères le Châtel, France. [email protected]

DOI: 10.1093/rpd/ncq429

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MeSH Terms: Actinoid Series Elements, Algorithms, Bile, Chelating Agents, Computer Simulation, Feces, Humans, Liver, Models, Biological, Models, Theoretical, Pentetic Acid, Radiation Injuries, Radiation Protection, Radiation-Protective Agents, Urine