Modulatory action of α-tocopherol on erythrocyte membrane adenosine triphosphatase against radiation damage in oral cancer.

Subramaniam Chitra, Chennam Srinivasulu Shyamaladevi

Journal: The Journal of membrane biology 2011;240(2):83-8

PMID: 21327633

Abstract

To investigate the possible effects of α-tocopherol on erythrocyte membrane adenosine triphosphatases against radiation damage in oral cancer patients. Adenosine triphosphatase activities were analysed in oral cancer patients before and after radiotherapy (at a dosage of 6000 cGY in five fractions per week for a period of six weeks) and after supplemented with α-tocopherol (400 IU per day for entire period of radiotherapy). The membrane bound enzymes such as Na(+)/K(+)-ATPase, Ca(2+)-ATPase, Mg(2+)-ATPase and some trace elements were altered in oral cancer patients before and after radiotherapy. Supplemented with α-tocopherol modulates the erythrocyte membrane which is damaged by radiotherapy which suggests that α-tocopherol protects the erythrocyte membrane from radiation damage in oral cancer patients.

Address: Department of Biotechnology, Sri Ramachandra University, Chennai, India. [email protected]

DOI: 10.1007/s00232-011-9346-x

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https://dx.doi.org/10.1007/s00232-011-9346-x

MeSH Terms: Adenosine Triphosphatases, Adult, Aged, Ca(2+) Mg(2+)-ATPase, Dietary Supplements, Erythrocyte Membrane, Female, Humans, Male, Middle Aged, Mouth Neoplasms, Radiation Injuries, Sodium-Potassium-Exchanging ATPase, Time Factors, alpha-Tocopherol