Nanoparticle-based electrochemical detection in conventional and miniaturized systems and their bioanalytical applications: a review.

Weena Siangproh, Wijitar Dungchai, Poomrat Rattanarat, Orawon Chailapakul

Journal: Analytica chimica acta 2011;690(1):10-25

PMID: 21414432

Full Text on Elsevier Science View on PubMed

Abstract

With recent advances in nanotechnology making more easily available the novel chemical and physical properties of metal nanoparticles (NPs), these have become extremely suitable for creating new sensing assays. Many kinds of NPs, including metal, metal-oxide, semiconductor and even composite-metal NPs, have been used for constructing electrochemical sensors. This article reviews the progress of NP-based electrochemical detection in recent applications, especially in bioanalysis, and summarizes the main functions of NPs in conventional and miniaturized systems. All references cited here generally show one or more of the following characteristics: a low detection limit, good signal amplification and simultaneous-detection capabilities.

Address: Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukumvit 23 Rd., Wattana, Bangkok 10110, Thailand.

DOI: 10.1016/j.aca.2011.01.054

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MeSH Terms: Biosensing Techniques, DNA, Electrochemical Techniques, Glucose, Hydrogen Peroxide, Immunoassay, Miniaturization, Nanocomposites, Nanoparticles