Genome wide association studies of abdominal aortic aneurysms-biological insights and potential translation applications.

Steve E Humphries, Seamus C Harrison, Michael V Holmes, Obi Agu

Journal: Atherosclerosis 2012;217(1):47-56

PMID: 21414622

Full Text on Elsevier Science View on PubMed

Abstract

Abdominal aortic aneurysm (AAA) is a complex disease with important environmental risk factors and a heritability of approximately 70%. Genome wide association studies have revolutionised the study of complex disorders and offer the potential for innovative insight into disease pathogenesis and development of individualised therapeutic options. This paper reviews the progress of genome wide association studies in AAA, highlighting novel disease pathways and potential translational applications of genomic discoveries.

Address: Centre for Cardiovascular Genetics, BHF Laboratories, The Rayne Building, Department of Medicine, University College London (UCL), London WC1E 6JF, UK. [email protected]

DOI: 10.1016/j.atherosclerosis.2011.02.045

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MeSH Terms: Aortic Aneurysm, Abdominal, Case-Control Studies, Cholesterol, Chromosomes, Human, Pair 9, Disease Progression, Female, Genome-Wide Association Study, Genomics, Humans, Male, Polymorphism, Single Nucleotide, Translational Research, Biomedical