Mechanisms of aneuploidy and its suppression by tumour suppressor proteins.

Claudio R Thoma, Alberto Toso, Patrick Meraldi, Wilhelm Krek

Journal: Swiss medical weekly 2011;141():w13170

PMID: 21384284

Free Full Text on SMW supporting association (Trägerverein Swiss Medical Weekly SMW) View on PubMed

Abstract

Aneuploidy, as a result of numerical changes in chromosome number, was observed in tumours almost a century ago. The molecular mechanisms underlying this phenomenon and their impact on tumour development are still poorly understood. A series of recent observations provide direct linkages between the normal function of tumour suppressor proteins and the suppression of aneuploidy. The prospects that these findings offer for understanding the role of aneuploidy in cancer are discussed in this review.

Address: Institute of Cell Biology, ETH Zurich, Switzerland. [email protected]

DOI: 10.4414/smw.2011.13170

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MeSH Terms: Adenomatous Polyposis Coli Protein, Aneuploidy, Chromosomal Instability, Genes, cdc, Humans, Neoplasms, Repressor Proteins, Retinoblastoma Protein, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, Von Hippel-Lindau Tumor Suppressor Protein