Enabling anticancer therapeutics by nanoparticle carriers: the delivery of Paclitaxel.

Bing Yan, Bin Zhang, Yongjin Liu

Journal: International journal of molecular sciences 2015;12(7):4395-413

PMID: 21845085

Abstract

Anticancer drugs, such as paclitaxel (PTX), are indispensable for the treatment of a variety of malignancies. However, the application of most drugs is greatly limited by the low water solubility, poor permeability, or high efflux from cells. Nanoparticles have been widely investigated to enable drug delivery due to their low toxicity, sustained drug release, molecular targeting, and additional therapeutic and imaging functions. This review takes paclitaxel as an example and compares different nanoparticle-based delivery systems for their effectiveness in cancer chemotherapy.

Address: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China; E-Mails: [email protected] (Y.L.); [email protected] (B.Z.).

DOI: 10.3390/ijms12074395

Link outs

Free resources

Full Text Sources:

Other Literature Sources:

https://www.lens.org/lens/search/patent/list?q=ref...

MeSH Terms: Antineoplastic Agents, Phytogenic, Drug Carriers, Humans, Lactic Acid, Magnetite Nanoparticles, Metal Nanoparticles, Nanoparticles, Nanotubes, Carbon, Neoplasms, Paclitaxel, Polyglycolic Acid, Polylactic Acid-Polyglycolic Acid Copolymer