The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders.

Elizabeta Nemeth, Tomas Ganz

Journal: Hematology. American Society of Hematology. Education Program 2012;2011():538-42

PMID: 22160086

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Abstract

The review summarizes the current understanding of the role of hepcidin and ferroportin in normal iron homeostasis and its disorders. The various approaches to therapeutic targeting of hepcidin and ferroportin in iron-overload disorders (mainly hereditary hemochromatosis and β-thalassemia) and iron-restrictive anemias (anemias associated with infections, inflammatory disorders, and certain malignancies, anemia of chronic kidney diseases, and iron-refractory iron-deficiency anemia) are also discussed.

Address: Department of Pulmonary & Critical Care Medicine, University of California-Los Angeles, Los Angeles, CA, USA. [email protected]

DOI: 10.1182/asheducation-2011.1.538

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MeSH Terms: Anemia, Antimicrobial Cationic Peptides, Cation Transport Proteins, Hepcidins, Humans, Iron Overload, Molecular Targeted Therapy, Ferroportin