Warfarin: to use or not to use in chronic kidney disease patients?

Vincent Brandenburg, Mario Cozzolino

Journal: Journal of nephrology 2011;23(6):648-52

PMID: 20349408

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Abstract

Is the risk of major bleeding the only reason to be concerned about oral anticoagulant therapy in chronic kidney disease patients? We consider another potential adverse effect of long-term Coumadin use in chronic kidney disease patients as comparably devastating: the threat of inducing creeping vascular calcification.

Address: Division of Nephrology, University of Milan, S. Paolo Hospital, Via A. di Rudini 8, Milan, Italy. [email protected]

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MeSH Terms: Anticoagulants, Calcium-Binding Proteins, Chronic Disease, Extracellular Matrix Proteins, Humans, Kidney Diseases, Kidney Failure, Chronic, Renal Dialysis, Warfarin, Matrix Gla Protein