Neuroimaging findings in alcohol-related encephalopathies.

Giulio Zuccoli, Nasir Siddiqui, Isabel Cravo, Ariel Bailey, Massimo Gallucci, Clive G Harper

Journal: AJR. American journal of roentgenology 2011;195(6):1378-84

PMID: 21098198

Abstract

OBJECTIVE

Our aim was to review the emergent neuroimaging findings of alcohol-related CNS nontraumatic disorders. Alcohol (ethanol) promotes inflammatory processes, increases DNA damage, and creates oxidative stress. In addition, the accompanying thiamine deficiency may lead to Wernicke encephalopathy. Associated changes in serum osmolarity may lead to acute demyelination.

CONCLUSION

Alcohol-related encephalopathies can be life-threatening conditions but can be prevented or treated, if recognized.

Address: Department of Radiology, University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh, One Children's Hospital Drive, 4401 Penn Avenue, Pittsburgh, PA 15224, USA. [email protected]

DOI: 10.2214/AJR.09.4130

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MeSH Terms: Alcohol-Induced Disorders, Nervous System, Avitaminosis, Brain, DNA Damage, Diagnostic Imaging, Humans, Oxidative Stress, Wernicke Encephalopathy