Insulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer.

P Massoner, M Ladurner-Rennau, I E Eder, H Klocker

Journal: British journal of cancer 2011;103(10):1479-84

PMID: 20924377

Free Full Text on PubMed Central View on PubMed

Abstract

Insulin-like growth factor (IGF) and insulin (INS) proteins regulate key cellular functions through a complex interacting multi-component molecular network, known as the IGF/INS axis. We describe how dynamic and multilayer interactions give rise to the multifunctional role of the IGF/INS axis. Furthermore, we summarise the importance of the regulatory IGF/INS network in cancer, and discuss the possibilities and limitations of therapies targeting the IGF/INS axis with reference to ongoing clinical trials concerning the blockage of IGF1R in several types of cancer.

Address: Section of Experimental Urology, Department of Urology, Innsbruck Medical University, Anichstr. 35, Innsbruck 6020, Austria. [email protected]

DOI: 10.1038/sj.bjc.6605932

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/diabetesmedicines.html

Subscription / membership required

Full Text Sources:

https://doi.org/10.1038/sj.bjc.6605932

MeSH Terms: Amino Acids, Disease Progression, Fatty Acids, Glucose, Glycogen, Homeostasis, Humans, Insulin, Insulin-Like Growth Factor Binding Proteins, Neoplasms, Receptor, IGF Type 2, Signal Transduction, Somatomedins