Pathogenic Role of Serine Protease HtrA2/Omi in Neurodegenerative Diseases.

Hui-Gwan Goo, Hyangshuk Rhim, Seongman Kang

Journal: Current protein & peptide science 2017;18(7):746-757

PMID: 26965693

Abstract

High-temperature-requirement A2 (HtrA2)/Omi/PARK13 is a serine protease with extensive homology to the Escherichia coli HtrAs that are required for bacterial survival at high temperatures. The HtrA2 protein is a key modulator of mitochondrial molecular quality control but under stressful conditions it is released into the cytosol, where it promotes cell death by various pathways, including caspase-dependent pathway and ER stress-mediated apoptosis. Recently, the HtrA2 protein has received great attention for its potential role in neurodegeneration. Here, we review the current knowledge and pathophysiological functions of the HtrA2 protein in neurodegenerative disorders such as Parkinson's and Alzheimer's disease.

Address: Division of Life Sciences, Korea University, Seoul 136-701, Korea.; Department of Biomedical Sciences, Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.; Division of Life Sciences, Korea University, 1, 5ka, Anam-dong, Sungbuk-gu, Seoul 136-701, Korea.

DOI: 10.2174/1389203717666160311115750

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MeSH Terms: Alzheimer Disease, Caspases, Catalytic Domain, Cell Death, Endoplasmic Reticulum Stress, Escherichia coli, Escherichia coli Proteins, High-Temperature Requirement A Serine Peptidase 2, Humans, Mitochondria, Mitochondrial Proteins, Parkinson Disease, Proteolysis, Sequence Homology, Amino Acid, Serine Endopeptidases, Substrate Specificity