Isolated tramadol overdose associated with Brugada ECG pattern.

Jon B Cole, Srinivasan Sattiraju, Elisabeth F Bilden, Richard W Asinger, Stefan C Bertog

Journal: Pacing and clinical electrophysiology : PACE 2013;35(8):e219-21

PMID: 21039643

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Abstract

Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication.

Address: Hennepin Regional Poison Center, Minneapolis, Minnesota, USA.

DOI: 10.1111/j.1540-8159.2010.02924.x

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MeSH Terms: Analgesics, Opioid, Brugada Syndrome, Humans, Male, Middle Aged, Naloxone, Narcotic Antagonists, Prescription Drug Misuse, Sodium Channel Blockers, Tramadol, Treatment Outcome