Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design.

Takeshi Ichinohe

Journal: Expert review of vaccines 2011;9(11):1315-24

PMID: 21087109

Abstract

Influenza A virus is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. It has become increasingly evident that influenza viral infection is recognized by at least three classes of pattern-recognition receptors, including TLR-7, the retinoic acid inducible gene-I and nucleotide-binding domain and leucine-rich-repeat-containing protein 3, a member of the Nod-like receptor family. This article highlights the roles of different types of innate immune receptors in influenza virus immunity versus immunopathology.

Address: Department of Virology, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. [email protected]

DOI: 10.1586/erv.10.118

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MeSH Terms: Carrier Proteins, DEAD Box Protein 58, DEAD-box RNA Helicases, Humans, Immunity, Innate, Influenza A virus, Influenza Vaccines, Influenza, Human, NLR Family, Pyrin Domain-Containing 3 Protein, Receptors, Immunologic, Toll-Like Receptor 7