Intestinal receptor targeting for peptide delivery: an expert's personal perspective on reasons for failure and new opportunities.

Gregory Russell-Jones

Journal: Therapeutic delivery 2012;2(12):1575-93

PMID: 22833983

Abstract

The technology has been available more than 25 years that would enable the oral delivery of vaccines, proteins and peptides, thus avoiding the need for injection. To this day, injection is still the mode of delivery, yet not the main mode of choice. This review focuses on several of the potential modes for oral delivery of peptides, proteins and vaccines. Additionally, the review will provide the reader with an insight into the problems and potential solutions for several of these modes of oral delivery of peptides and proteins.

Address: Mentor Pharmaceutical Consulting Pty Ltd, 23 Greenfield Ave, Middle Cove, NSW 2068, Australia. [email protected]

DOI: 10.4155/tde.11.129

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MeSH Terms: Administration, Oral, Drug Delivery Systems, Intestinal Mucosa, Nanoparticles, Peptides, Receptor, Insulin, Receptors, Cell Surface, Receptors, IgG, Transcytosis, Vitamin B 12