A spatial model of cellular molecular trafficking including active transport along microtubules.

A Cangiani, R Natalini

Journal: Journal of theoretical biology 2011;267(4):614-25

PMID: 20816682

Full Text on Elsevier Science View on PubMed

Abstract

We consider models of Ran-driven nuclear transport of molecules such as proteins in living cells. The mathematical model presented is the first to take into account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The model is tested by numerical simulations based on discontinuous Galerkin finite element methods. The numerical experiments are compared to the behavior observed experimentally.

Address: Dipartimento di Matematica e Applicazioni, Università di Milano Bicocca, via Cozzi, 53; I-20125 Milano, Italy.

DOI: 10.1016/j.jtbi.2010.08.017

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MeSH Terms: Biological Transport, Active, Cells, Diffusion, Karyopherins, Kinetics, Microtubules, Models, Biological, Nuclear Envelope, Numerical Analysis, Computer-Assisted, Permeability, Retinoblastoma Protein