Lipidomics: coming to grips with lipid diversity.

Kai Simons, Andrej Shevchenko

Journal: Nature reviews. Molecular cell biology 2010;11(8):593-8

PMID: 20606693

Full Text on Nature Publishing Group View on PubMed

Abstract

Although lipids are biomolecules with seemingly simple chemical structures, the molecular composition of the cellular lipidome is complex and, currently, poorly understood. The exact mechanisms of how compositional complexity affects cell homeostasis and its regulation also remain unclear. This emerging field is developing sensitive mass spectrometry technologies for the quantitative characterization of the lipidome. Here, we argue that lipidomics will become an essential tool kit in cell and developmental biology, molecular medicine and nutrition.

Address: Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

DOI: 10.1038/nrm2934

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MeSH Terms: Disease, Humans, Lipid Metabolism, Lipids, Mass Spectrometry, Membrane Lipids, Membrane Proteins, Metabolomics, Molecular Structure