Roles of Vpr and Vpx in modulating the virus-host cell relationship.

Vicente Planelles, Edward Barker

Journal: Molecular aspects of medicine 2011;31(5):398-406

PMID: 20558198

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Abstract

The human and simian immunodeficiency viruses contain small open reading frames known as vpr and vpx. These genes encode proteins that are highly related both at the amino acid level and functionally, although key differences do exist. This review describes the main functions ascribed to Vpr and Vpx in the context of both viral replication and modulation of host cell biology.

Address: Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, #2100 - Room 2520, Salt Lake City, UT 84112, USA. [email protected]

DOI: 10.1016/j.mam.2010.05.002

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MeSH Terms: Apoptosis, Cell Cycle, DNA Damage, Host-Pathogen Interactions, Humans, Simian Immunodeficiency Virus, Viral Regulatory and Accessory Proteins, vpr Gene Products, Human Immunodeficiency Virus