Meta-analysis on the effect of the Ala54Thr polymorphism of the fatty acid-binding protein 2 gene on body mass index.

BACKGROUND AND AIM

The results from studies published on the association of fatty acid-binding protein 2 (FABP2) Ala54Thr polymorphism with body mass index (BMI) are conflicting. In this meta-analysis, we investigated the association of the FABP2 Ala54Thr polymorphism with BMI.

METHODS AND RESULTS

We searched for articles published prior to June 2009 using PubMed, HugeNavigator and China National Knowledge Internet. The languages were limited to English and Chinese. Data on BMI were collected. A pooled weighted mean difference (WMD), together with 95% confidence interval (CI), was used for this meta-analysis. A total of 27 studies with 10 974 subjects were included in this meta-analysis. The pooled effect for dominant, recessive and co-dominant model comparisons did not suggest the significant association between the FABP2 Ala54Thr polymorphism and BMI in overall populations: WMD(fixed effects)=-0.00, 95% CI: (-0.16 to 0.15), p=0.99, WMD(random effects)=-0.00, 95% CI: (-0.16 to 0.15), p=0.99, p(Q)=0.77, I(2)=0%, WMD(fixed effects)=-0.12, 95% CI: (-0.39 to 0.14), p=0.35, WMD(random effects)=-0.12, 95% CI: (-0.39 to 0.14), p=0.35, p(Q)=0.47, I(2)=0% and WMD(fixed effects)=0.07, 95% CI: (-0.11 to 0.25), p=0.45, WMD(random effects)=0.07, 95% CI: (-0.11 to 0.25), p=0.45, p(Q)=0.90, I(2)=0%, respectively. The results from the comparisons of ThrThr versus AlaAla and AlaThr versus AlaAla showed no evidence that the FABP2 Ala54Thr polymorphism is significantly associated with BMI in overall populations (p>0.05). All the results from the subgroup analyses for these genetic models comparisons were not significant (p>0.05).

CONCLUSIONS

Our meta-analysis does not support the association between the FABP2 Ala54Thr polymorphism and BMI.

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