In vitro evaluation of ketoprofen controlled release from various formulations.

Ana-Maria Oprea, Raluca Petronela Dumitriu, Cătălina Cheaburu, Cornelia Vasile

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 2011;114(3):829-35

PMID: 21235124

Abstract

UNLABELLED

The aim of this study is to investigate the potential utility of some hydrogels, based on chitosan, chitosan modified with phthalic anhydride and 75/25 poly(N-isopropyl acrylamide)/alginate, for preparing drug release systems containing ketoprofen, as model drug.

MATERIAL AND METHOD

The in vitro release profiles and swelling studies were done in ethanol medium, where the studied drug presents high solubility, at 25 degrees C (room temperature). The ketoprofen release was observed by monitoring the absorbance at max = 254 nm as a function of time.

RESULTS

The experimental results indicated that the smallest amount of drug was released from chitosan matrices, appreciatively 31%.

CONCLUSIONS

The composition of hydrogels had an important effect on ketoprofen release.

Address: Physical Chemistry of Polymers Department, P. Poni Institute of Macromolecular Chemistry laşi.

MeSH Terms: Alginates, Anti-Inflammatory Agents, Non-Steroidal, Biocompatible Materials, Chitosan, Ethanol, Glucuronic Acid, Hexuronic Acids, Hydrogels, In Vitro Techniques, Ketoprofen, Phthalic Anhydrides, Solubility, Temperature