High factor XI, recurrent pregnancy loss, enoxaparin.

Charles J Glueck, Joel Pranikoff, Naseer Khan, Kashif Riaz, Kirti Chavan, Pavithra Raj, Muhammad Umar, Ping Wang

Journal: Fertility and sterility 2011;94(7):2828-31

PMID: 21094629

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Abstract

Of the 149 women with 0 pregnancy losses, 7 (5%) had factor XI level ≥150% versus 5 of 31 (16%) women with recurrent pregnancy loss. Three of the 5 women with high factor XI and recurrent pregnancy loss, with 19 previous pregnancy losses and 0 live births, were given enoxaparin during 5 subsequent pregnancies, and had 6 term live births and 1 miscarriage.

Address: Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA. [email protected]

DOI: 10.1016/j.fertnstert.2009.12.084

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MeSH Terms: Abortion, Habitual, Anticoagulants, Cohort Studies, Embryo Loss, Enoxaparin, Factor XI, Female, Homozygote, Humans, Methylenetetrahydrofolate Reductase (NADPH2), Mutation, Missense, Pregnancy, Pregnancy Complications, Hematologic, Pregnancy Rate, Up-Regulation