Portuguese winemaking residues as a potential source of natural anti-adenoviral agents.

Ana A Matias, Ana Teresa Serra, A Carina Silva, Ricardo Perdigão, Tiago B Ferreira, I Marcelino, Sandra Silva, Ana V Coelho, Paula M Alves, Catarina M M Duarte

Journal: International journal of food sciences and nutrition 2010;61(4):357-68

PMID: 20109126

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Abstract

To date there are no licensed systemic or topical treatments in Europe or the USA for adenovirus infections. In the present paper, we evaluate the effect of a polyphenol-based grape extract (NE) obtained from Portuguese white-winemaking by-products, and Resveratrol in pure form, on adenovirus type 5 infection. For this purpose, recombinant adenovirus vectors (Ad-5) and a human-derived cell line (293) were used as models. The NE and Resveratrol at the used concentrations do not induce cell cytotoxicity or direct virucidal activity; however, they reduce 4.5 and 6.5 log (TCID(50)/ml) on total infectious Ad-5 production, respectively. The capacity of Ad-5 replication upon removal of NE and Resveratrol after 24 h post infection was also evaluated. In contrast to Resveratrol, the highest evaluated NE concentration inhibits irreversibly the Ad-5 replication. These results provide useful information for the use of NE and Resveratrol as potential sources of promising natural antiviral agents on Ad-5 infection.

Address: Instituto de Biologia Experimental e Tecnológica, Avenida da República, Quinta do Marquês, Estação Agronómica Nacional, Oeiras, Portugal.

DOI: 10.3109/09637480903430990

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MeSH Terms: Adenoviridae, Adenovirus Infections, Human, Antiviral Agents, Cell Line, Flavonoids, Food Industry, Fruit, Genetic Vectors, Humans, Industrial Waste, Phenols, Plant Extracts, Polyphenols, Portugal, Resveratrol, Stilbenes, Virus Replication, Vitis, Wine