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Post-transcriptional global regulation by CsrA in bacteria.

Johan Timmermans, Laurence Van Melderen

Journal: Cellular and molecular life sciences : CMLS 2010;67(17):2897-908

PMID: 20446015

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Abstract

Global regulation allows bacteria to rapidly modulate the expression of a large variety of unrelated genes in response to environmental changes. Global regulators act at different levels of gene expression. This review focuses on CsrA, a post-transcriptional regulator that affects translation of its gene targets by binding mRNAs. CsrA controls a large variety of physiological processes such as central carbon metabolism, motility and biofilm formation. The activity of CsrA is itself tightly regulated by the CsrB and CsrC small RNAs and the BarA-UvrY two-component system.

Address: Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, 6041, Gosselies, Belgium.
DOI: 10.1007/s00018-010-0381-z

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MeSH Terms: Amino Acid Sequence, Biofilms, Carbon, Escherichia coli Proteins, Gene Expression Regulation, Bacterial, Membrane Proteins, Models, Biological, Molecular Sequence Data, Phosphotransferases, RNA, Messenger, RNA, Small Nuclear, RNA-Binding Proteins, Repressor Proteins, Transcription Factors
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