Montelukast therapy and psychological distress in chronic obstructive pulmonary disease (COPD): a preliminary report.

Nicolò Gueli, Walter Verrusio, Adele Linguanti, Wladimiro De Santis, Nicoletta Canitano, Flora Ippoliti, Vincenzo Marigliano, Mauro Cacciafesta

Journal: Archives of gerontology and geriatrics 2011;52(1):e36-9

PMID: 20478636

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Abstract

Chronic obstructive pulmonary disease (COPD) is an alteration in which ventilatory function, exercise capacity and health status of patients progressively decline and it is characterized by an increase of inflammatory cytokines such as TNF-α, LTB4, IL-8, etc. In this study we considered twenty patients (15 males and 5 females; mean age: 72.8 ± 6.3) with stable COPD. All patients were performed evaluation of psychological stress at enrollment and were treated with leukotriene receptor antagonists (montelukast tablets) 10mg/day for 12 months. After 12 months we observed a significant decrease of serum levels of LTB4, IL-8 and also a decrease of the number of outpatient clinic visits, of the number of hospitalizations and of the duration of hospitalization.

Address: Department of Aging Science, Policlinico Umberto I, Sapienza University of Rome, viale del Policlinico, 155, I-00161 Roma, Italy. [email protected]

DOI: 10.1016/j.archger.2010.04.014

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MeSH Terms: Acetates, Aged, Anti-Asthmatic Agents, Cyclopropanes, Female, Hospitalization, Humans, Interleukin-8, Leukotriene B4, Male, Pulmonary Disease, Chronic Obstructive, Quinolines, Stress, Psychological, Sulfides, Tumor Necrosis Factor-alpha