Modulation of apoptosis by natural products for cancer therapy.

Simone Fulda

Journal: Planta medica 2010;76(11):1075-9

PMID: 20486070

Full Text on Georg Thieme Verlag Stuttgart, New York View on PubMed

Abstract

Natural products can exhibit many beneficial effects on human health. As far as cancer is concerned, naturally occurring compounds have been reported to prevent tumorigenesis and also to suppress the growth of established tumors. As cancer cells have evolved multiple mechanisms to resist the induction of programmed cell death (apoptosis), the modulation of apoptosis signaling pathways by natural compounds has been demonstrated to constitute a key event in these antitumor activities. This review presents some examples of how apoptosis pathways are targeted by selected naturally occurring agents and how these events can be exploited for cancer therapy.

Georg Thieme Verlag KG Stuttgart-New York.

Address: Children's Hospital, Ulm University, Ulm, Germany. [email protected]

DOI: 10.1055/s-0030-1249961

Link outs

Free resources

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

Subscription / membership required

Full Text Sources:

https://www.thieme-connect.com/DOI/DOI?10.1055/s-0...

MeSH Terms: Antineoplastic Agents, Phytogenic, Apoptosis, Clinical Trials as Topic, Gossypol, Humans, Mitochondria, Neoplasms, Pentacyclic Triterpenes, Reactive Oxygen Species, Resveratrol, Signal Transduction, Stilbenes, Triterpenes, Vitamin E, Betulinic Acid