Physiological roles of the TRPM4 channel extracted from background currents.

Romain Guinamard, Marie Demion, Pierre Launay

Journal: Physiology (Bethesda, Md.) 2010;25(3):155-64

PMID: 20551229

Abstract

Calcium-activated nonselective cationic currents have been known for 30 years, but their physiological implications have remained unresolved until the recent cloning of the TRPM4 ion channel. Since then, TRPM4 has been identified as a key modulator of numerous calcium-dependent mechanisms such as the immune response, insulin secretion, cerebral artery constriction, respiratory rhythm, and cardiac conduction.

Address: Groupe Coeur et Ischémie, Université de Caen, Caen, France. [email protected]

DOI: 10.1152/physiol.00004.2010

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MeSH Terms: Heart Conduction System, Humans, Immunity, Respiratory Mechanics, Signal Transduction, TRPM Cation Channels, Vasoconstriction