Herpes simplex virus type 1 persists in the aged brain through hypothetical expression of accessory genes.

Isamu Mori

Journal: Journal of neurovirology 2010;16(3):203-7

PMID: 20450378

Abstract

Herpes simplex virus type 1 persists in the brain of most aged individuals and may contribute to the pathogenesis of Alzheimer's disease. The virus likely utilizes accessory genes for neural spread within the nervous system and herpes simplex virus type 1 may regulate various host responses through an array of accessory genes. This mini-review focuses on these viral accessory genes that may shed light on the potential mechanisms of this enigmatic phenomenon in the elderly brain.

Address: Faculty of Health and Nutrition, Shubun University, Aichi, Japan. [email protected]

DOI: 10.3109/13550281003739040

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https://dx.doi.org/10.3109/13550281003739040

MeSH Terms: Aged, Aging, Alzheimer Disease, Brain, Encephalitis, Herpes Simplex, Gene Expression Regulation, Viral, Herpes Simplex, Herpesvirus 1, Human, Humans