Anti-allergic drugs and the Annexin-A1 system.

Samia Yazid, Samir S Ayoub, Egle Solito, Simon McArthur, Phuong Vo, Neil Dufton, Roderick J Flower

Journal: Pharmacological reports : PR 2010;62(3):511-7

PMID: 20631415

Free Full Text on Institute of Pharmacology Polish Academy of Sciences View on PubMed

Abstract

This paper, which was presented at the 17th JMRC 'John Robert Vane Memorial' Symposium, describes some recent work from the authors' laboratory that provides a tentative explanation for the anti-inflammatory effects produced by the cromoglycate-like anti-allergic drugs. Some of the implications of this finding are discussed.

Address: Biochemical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

DOI: 10.1016/s1734-1140(10)70307-8

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MeSH Terms: Annexin A1, Anti-Allergic Agents, Cromolyn Sodium, Humans, Inflammation, Mast Cells, U937 Cells