Cellular blue nevus (CBN) lymph node metastases of the neck with no primary skin lesion: a case report and review of literature.

Konstanze Scheller, Christian Scheller, Susann Becker, Hans-Jürgen Holzhausen, Johannes Schubert

Journal: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 2011;38(8):601-4

PMID: 20223677

Full Text on Elsevier Science View on PubMed

Abstract

A case of cervical lymph node infiltration by a benign cellular blue nevus (CBN) and a 27-year disease history is presented. Dermal dendritic melanocytes and pigmented spindle cells presented no histological evidence of malignancy (CD34-, desmin-, PanCy-, HMB-45+, anti-S-100+, Bcl-2+, MART-1+, focally expression of melan A, 1% Ki-67+ of the tumour cell nucleoli). The differentiation of the benign blue nevus (BN) from a malignant blue nevus (MBN) and a malignant melanoma (MM) is still a challenge. Because of the malignant transformation potential of 5.2-6.3% a histological examination and a conservative surgical approach with close follow up are mandatory.

Address: Department of Oral and Maxillofacial Surgery, Martin-Luther-University Halle-Wittenberg, Germany.

DOI: 10.1016/j.jcms.2010.01.008

Link outs

Free resources

Medical:

https://medlineplus.gov/skincancer.html

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-1142

Subscription / membership required

Full Text Sources:

MeSH Terms: Diagnosis, Differential, Humans, Lymph Nodes, Lymphatic Metastasis, Male, Melanoma, Middle Aged, Neck, Nevus, Blue, Skin Neoplasms, Treatment Outcome