Genome-wide association studies in pharmacogenomics.

Ann K Daly

Journal: Nature reviews. Genetics 2011;11(4):241-6

PMID: 20300088

Full Text on Nature Publishing Group View on PubMed

Abstract

Genome-wide association (GWA) studies for pharmacogenomics-related traits are increasingly being performed to identify loci that affect either drug response or susceptibility to adverse drug reactions. Until now, only the largest effects have been detected, partly because of the challenges of obtaining large numbers of cases for pharmacogenomic studies. Since 2007, a range of pharmacogenomics GWA studies have been published that have identified several interesting and novel associations between drug responses or reactions and clinically relevant loci, showing the value of this approach.

Address: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. [email protected]

DOI: 10.1038/nrg2751

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MeSH Terms: Anticoagulants, Aryl Hydrocarbon Hydroxylases, Chemical and Drug Induced Liver Injury, Cytochrome P-450 CYP2C9, Drug-Related Side Effects and Adverse Reactions, Floxacillin, Genome-Wide Association Study, Humans, Interferon-alpha, Mixed Function Oxygenases, Muscular Diseases, Pharmacogenetics, Platelet Aggregation Inhibitors, Simvastatin, Vitamin K Epoxide Reductases