The effect of Rexflavone (Sophorae fructus extract) on menopausal symptoms in postmenopausal women: a randomized double-blind placebo controlled clinical trial.

Jeongrai Lee, Kuk Whan Kim, Hyun-Kyu Kim, Soo-Wan Chae, Jae-Chul Jung, Suk Hyung Kwon, Chul Hee Rheu

Journal: Archives of pharmacal research 2010;33(4):523-30

PMID: 20422360

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Abstract

To observe the protective effect of orally administrated Rexflavone (Sophorae fructus extract) for the postmenopausal symptoms, a randomized double-blind placebo controlled clinical trial was designed. Rexflavone significantly improved 11 menopausal symptoms including hot flash, which was evaluated by the modified Kupperman Index (KI), while hormone level and lipid profile were little changed by consumption. Rexflavone group significantly decreased KI score (-14.91 +/- 8.79) compared to placebo group (-11.45 +/- 6.62) as a representative index for improvement of menopausal symptoms (p < 0.05). We found that Rexflavone has no adverse effect to be safe for long term consumption. It was shown that the consumption of Rexflavone possessed beneficial effects on the postmenopausal symptoms in postmenopausal women.

Address: RexGene Biotech. Co., Ltd. Research and Development of Life Science, Ochang, 368-831, Korea.

DOI: 10.1007/s12272-010-0405-0

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MeSH Terms: Administration, Oral, Adult, Affective Symptoms, Anxiety, Dietary Supplements, Double-Blind Method, Estradiol, Female, Follicle Stimulating Hormone, Fruit, Hot Flashes, Humans, Hypesthesia, Lipids, Middle Aged, Phytotherapy, Plant Extracts, Postmenopause, Sophora, Treatment Outcome