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Dual role of parathyroid hormone in endothelial progenitor cells and marrow stromal mesenchymal stem cells.

Giovanni Di Bernardo, Umberto Galderisi, Carmela Fiorito, Tiziana Squillaro, Letizia Cito, Marilena Cipollaro, Antonio Giordano, Claudio Napoli

Journal: Journal of cellular physiology 2009;222(2):474-80

PMID: 19918796

Full Text on Wiley View on PubMed

Abstract

Hematopoietic stem cells derive regulatory information also from parathyroid hormone (PTH). To explore the possibility that PTH may have a role in regulation of other stem cells residing in bone marrow, such as mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) we assessed the effect of this hormone on the in vitro behavior of MSCs and EPCs. We evidenced that MSCs were much more responsive to PTH than EPCs. PTH increased the proliferation rate of MSCs with a diminution of senescence and apoptosis. Taken together, our results may suggest a protective effect of PTH on MSCs that reduces stress phenomena and preserve genome integrity. At the opposite, PTH did not modify the fate of EPCs in culture.

(c) 2009 Wiley-Liss, Inc.

Address: Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Second University of Naples, Naples, Italy.
DOI: 10.1002/jcp.21976

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MeSH Terms: 8-Hydroxy-2'-Deoxyguanosine, Apoptosis, Bone Marrow Cells, Cell Differentiation, Cell Proliferation, Cells, Cultured, Cellular Senescence, DNA Damage, Deoxyguanosine, Endothelial Cells, Gene Expression Regulation, Humans, Mesenchymal Stem Cells, Parathyroid Hormone, RNA, Messenger, Receptors, Parathyroid Hormone, Retinoblastoma Protein, Stem Cells, Stromal Cells, Time Factors, Tumor Suppressor Protein p53
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