Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa.

Javier Espino, Ignacio Bejarano, Agueda Ortiz, Graciela M Lozano, Juan F García, José A Pariente, Ana B Rodríguez

Journal: Fertility and sterility 2010;94(5):1915-7

PMID: 20152967

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Abstract

It is assumed somatic cells can die in the apoptotic, the autophagic, or the necrotic way; however, the mechanisms of sperm death are not clear. Here, ejaculated human spermatozoa were evaluated for apoptosis and reactive oxygen species production in the absence or presence of melatonin, and we concluded that melatonin reverses sperm apoptosis due to its free radical scavenging actions.

Address: Department of Physiology, Faculty of Science, University of Extremadura, Badajoz, Spain.

DOI: 10.1016/j.fertnstert.2009.12.082

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MeSH Terms: Apoptosis, Caspase 3, Caspase 9, Ejaculation, Free Radical Scavengers, Humans, Hydrogen Peroxide, Male, Melatonin, Oxidative Stress, Reactive Oxygen Species, Spermatozoa