Effect of atorvastatin on cellular adhesion molecules on leukocytes in patients with normocholesterolemic coronary artery disease.

Thomas Walter, Tim Suselbeck, Martin Borggrefe, Stefanie Swoboda, Hans Martin Hoffmeister, Carl-Erik Dempfle

Journal: In vivo (Athens, Greece) 2010;24(2):189-93

PMID: 20363993

Abstract

BACKGROUND

Expression of cellular adhesion molecules on leukocytes plays a key role in coronary artery disease (CAD). The aim of the present study was to assess whether atorvastatin therapy has an impact on the expression of cellular adhesion molecules on leukocytes in patients with normocholesterolemic CAD.

PATIENTS AND METHODS

In 54 patients with CAD and atorvastatin treatment and 54 CAD patients without atorvastatin therapy, expression of CD40L, CD11a, CD11b, CD54, CD62L and CD41 on leukocytes was measured using flow cytometry. All patients were normocholesterolemic.

RESULTS

Atorvastatin treatment led to a significantly lower expression of CD40L, CD11b and CD54 on monocytes (p<0.05) and neutrophils (p<0.05). Expression of CD11a was significantly lower on monocytes (p<0.05) in atorvastatin-treated patients.

CONCLUSION

The present results indicate that atorvastatin apparently improves chronic inflammation and may have a beneficial effect on hemostasis by reducing the expression of cellular adhesion molecules on leukocytes.

Address: University Medical Centre Mannheim, First Department of Medicine, D-68167 Mannheim, Germany. [email protected]

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MeSH Terms: Aged, Atorvastatin, CD11a Antigen, CD11b Antigen, CD40 Ligand, Cell Adhesion Molecules, Cholesterol, Coronary Artery Disease, Female, Flow Cytometry, Heptanoic Acids, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Intercellular Adhesion Molecule-1, L-Selectin, Leukocytes, Male, Middle Aged, Platelet Membrane Glycoprotein IIb, Pyrroles