Prucalopride for constipation.

Michael Camilleri, Annemie Deiteren

Journal: Expert opinion on pharmacotherapy 2010;11(3):451-61

PMID: 20102308

Abstract

IMPORTANCE OF THE FIELD

Chronic constipation has a high prevalence, and current medical and pharmacological therapies do not restore normal bowel function in all patients.

AREAS COVERED IN THE REVIEW

A PubMed search (1965 - 2009) using the following terms alone or in combination: prucalopride, 5-HT(4), R093877, safety, toxicity, pharmacokinetics, pharmacodynamics, transit, cardiac, hERG, arrhythmia, potassium current, elderly.

WHAT THE READER WILL GAIN

Understanding of the mechanisms of action, safety, efficacy and indications for prucalopride in patients with chronic constipation.

TAKE HOME MESSAGE

Prucalopride is an efficacious and generally safe, new therapeutic option in the management of chronic constipation.

Address: Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), College of Medicine, Mayo Clinic, Charlton 8-110, 200 First St S.W., Rochester, MN 55905, USA. [email protected]

DOI: 10.1517/14656560903567057

Link outs

Free resources

Medical:

https://medlineplus.gov/constipation.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-BRIP1-5

Subscription / membership required

Full Text Sources:

https://www.tandfonline.com/doi/10.1517/1465656090...

MeSH Terms: Aged, Benzofurans, Constipation, Defecation, Gastrointestinal Transit, Humans, Laxatives, Serotonin