Effect of probiotic supplementation in the first 6 months of life on specific antibody responses to infant Hepatitis B vaccination.

Shu E Soh, Dave Qi Rong Ong, Irvin Gerez, Xiaoe Zhang, Pavithra Chollate, Lynette Pei-Chi Shek, Bee Wah Lee, Marion Aw

Journal: Vaccine 2010;28(14):2577-9

PMID: 20105426

Full Text on Elsevier Science View on PubMed

Abstract

Probiotics have been shown to enhance specific immune responses to vaccines. We aim to assess the effect of probiotic supplementation on specific IgG antibody responses to Hepatitis B (HepB) vaccination in infants. Compared to controls, probiotic supplementation improved HepB surface antibody responses in subjects receiving monovalent doses of HepB vaccine at 0, 1 month and a DTPa-HepB combination vaccine at 6 months [placebo (n=28): 187.97 (180.70-195.24), probiotic (n=29): 345.70 (339.41-351.99)mIU/ml] (p=0.069), but not those who received 3 monovalent doses [placebo (n=68): 302.34 (296.31-308.37), probiotic (n=77): 302.06 (296.31-307.81)mIU/ml] (p=0.996). Probiotics may enhance specific antibody responses in infants receiving certain Hepatitis B vaccine schedules.

Address: Department of Paediatrics, Yong Loo Lin School of Medicine, National University Health System, Singapore 119074, Singapore.

DOI: 10.1016/j.vaccine.2010.01.020

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MeSH Terms: Diphtheria-Tetanus-Pertussis Vaccine, Female, Haemophilus Vaccines, Hepatitis B Antibodies, Hepatitis B Vaccines, Humans, Immunoglobulin G, Infant, Infant, Newborn, Male, Placebos, Probiotics