Efficacy and safety of oral propranolol premedication to reduce reflex tachycardia during hypotensive anesthesia with sodium nitroprusside in orthognathic surgery: a double-blind randomized clinical trial.

Benjamas Apipan, Duangdee Rummasak

Journal: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2010;68(1):120-4

PMID: 20006165

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Abstract

PURPOSE

The present study sought to determine whether premedication with oral propranolol 10 mg before hypotensive anesthesia with sodium nitroprusside could reduce reflex tachycardia, the amount of sodium nitroprusside used, and blood loss during hypotensive anesthesia for orthognathic surgery.

PATIENTS AND METHODS

A total of 60 patients undergoing bimaxillary surgery were studied in a prospective, randomized, and double-blind study of oral propranolol 10 mg or placebo as premedication before hypotensive anesthesia with sodium nitroprusside. Hemodynamic variables, the amount of sodium nitroprusside used, and blood loss were statistically analyzed.

RESULTS

The heart rate and amount of sodium nitroprusside used were highly significantly less (P < .01) in the propranolol group, but no significant difference was found in blood loss between the 2 groups. No clinically significant complications were observed in either group.

CONCLUSION

Premedication with oral propranolol 10 mg before hypotensive anesthesia with sodium nitroprusside is safe and effective to reduce reflex tachycardia and the amount of sodium nitroprusside used.

Address: Department of Surgery, Mahidol University Faculty of Dentistry, Bangkok, Thailand. [email protected]

DOI: 10.1016/j.joms.2009.07.065

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MeSH Terms: Administration, Oral, Adult, Anesthesia, General, Anti-Arrhythmia Agents, Baroreflex, Blood Loss, Surgical, Double-Blind Method, Female, Heart Rate, Humans, Hypotension, Controlled, Infusions, Intravenous, Male, Nitroprusside, Orthognathic Surgical Procedures, Premedication, Propranolol, Tachycardia, Vasodilator Agents