Wnt modulators in the biotech pipeline.

Jean-Philippe Rey, Debra L Ellies

Journal: Developmental dynamics : an official publication of the American Association of Anatomists 2010;239(1):102-14

PMID: 20014100

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Abstract

The purpose of this review is to provide a better understanding for the LRP co-receptor-mediated Wnt pathway signaling. Using proteomics, we have also subdivided the LRP receptor family into six sub-families, encompassing the twelve family members. This review includes a discussion of proteins containing a cystine-knot protein motif (i.e., Sclerostin, Dan, Sostdc1, Vwf, Norrin, Pdgf, Mucin) and discusses how this motif plays a role in mediating Wnt signaling through interactions with LRP.

Address: OsteoGeneX Inc., Kansas City, Kansas 66160, USA.

DOI: 10.1002/dvdy.22181

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MeSH Terms: Amino Acid Sequence, Biotechnology, Cystine Knot Motifs, LDL-Receptor Related Proteins, Ligands, Models, Molecular, Molecular Sequence Data, Proteomics, Signal Transduction, Wnt Proteins