The role of vitamin A in enhancing humoral immunity produced by antirabies vaccine.

F Q Siddiqui, M M Ahmad, F Kakar, S Akhtar, A S Dil

Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 2004;7(4-5):799-804

PMID: 15332782

Free Full Text on World Health Organization, Regional Office for the Eastern Mediterranean View on PubMed

Abstract

We tested the effects of vitamin A supplementation on the antibody titre of 40 healthy volunteers (age range: 10-35 years), who had received a complete course of antirabies vaccine (5 injections over 30 days). After determining the baseline serum vitamin A status of 80 volunteers, 20 pairs were matched for serum vitamin A level, body mass index, age, sex and socioeconomic status. One person from each pair was randomly assigned to an experimental or control group. The experimental group received vitamin A and antirabies vaccine. Controls received only the vaccine. The experimental group had significantly greater (2.1 times) serum antirabies titre than controls. This finding is an important step towards improving the economy of dosage of antirabies vaccines.

Address: Drugs Control and Traditional Medicines Division, Islamabad, Pakistan.

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https://medlineplus.gov/vitamina.html

MeSH Terms: Adolescent, Adult, Antibodies, Viral, Antibody Formation, Body Mass Index, Child, Chromatography, High Pressure Liquid, Combined Modality Therapy, Dietary Supplements, Drug Synergism, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunocompetence, Male, Pakistan, Rabies Vaccines, Rabies virus, Socioeconomic Factors, Surveys and Questionnaires, Treatment Outcome, Vaccination, Vitamin A, Vitamin A Deficiency