Distribution of DNA fragment sizes after irradiation with ions.

E Gudowska-Nowak, K Psonka-Antończyk, K Weron, T Elsässer, G Taucher-Scholz

Journal: The European physical journal. E, Soft matter 2010;30(3):317-24

PMID: 19823885

Abstract

Ionizing radiation is responsible for production of double-strand breaks (DSBs) in a DNA structure. In contrast to sparsely ionizing radiation, densely ionizing radiation produces DSBs that are non-randomly distributed along the DNA molecule and can form clusters of various size. The paper discusses minimalistic models that describe observable patterns of fragment length in DNA segments irradiated with heavy ions and applies the formalism to interpret the recent experimental data collected by use of atomic force microscope (AFM).

Address: Marian Smoluchowski Institute of Physics, Jagellonian University, Kraków, Poland. [email protected]

DOI: 10.1140/epje/i2009-10522-7

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https://dx.doi.org/10.1140/epje/i2009-10522-7

MeSH Terms: Bacteriophage phi X 174, DNA, DNA Fragmentation, DNA, Viral, Dose-Response Relationship, Radiation, Ions, Microscopy, Atomic Force, Models, Biological, Nickel, Plasmids