Experimental study of Love-wave immunosensors based on ZnO/LiTaO3 structures.

Feng-mei Zhou, Zhe Li, Li Fan, Shu-yi Zhang, Xiu-ji Shui

Journal: Ultrasonics 2010;50(3):411-5

PMID: 19880154

Full Text on Elsevier Science View on PubMed

Abstract

Experimental study of Love-mode immunosensors based on structures of ZnO/36 degrees YX-LiTaO3 is presented, in which the ZnO films with c-axis (002) orientation have been successfully grown on the 36 degrees YX-LiTaO3 substrates by RF magnetron sputtering technique. Then the Love-mode immunosensors based on the ZnO/36 degrees YX-LiTaO3 structures and monitoring antibody-antigen immunoreactions in aqueous solutions in real time are fabricated. The experimental results show that the optimal thickness of ZnO layers is about 1.20 microm in the structures deposited on 36 degrees YX-LiTaO3 substrates, which is much less than that of SiO2 overlayers about 6 microm. The antibody-antigen immunoreaction experiments also show that the frequency shifts of the sensors with 1.33 microm ZnO films are proportional to the concentration of antigen in solution as the concentration range less than 100 microg/ml.

Address: Lab of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093, PR China.

DOI: 10.1016/j.ultras.2009.09.024

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MeSH Terms: Acoustics, Biosensing Techniques, Computer-Aided Design, Equipment Design, Equipment Failure Analysis, Immunoassay, Lithium, Oxides, Tantalum, Zinc Oxide