Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer.

Alison M Michie, Alison M McCaig, Rinako Nakagawa, Milica Vukovic

Journal: The FEBS journal 2010;277(1):74-80

PMID: 19878310

Abstract

Death-associated protein kinase (DAPK) is a pro-apoptotic serine/threonine protein kinase that is dysregulated in a wide variety of cancers. The mechanism by which this occurs has largely been attributed to promoter hypermethylation, which results in gene silencing. However, recent studies indicate that DAPK expression can be detected in some cancers, but its function is still repressed, suggesting that DAPK activity can be subverted at a post-translational level in cancer cells. This review will focus on recent data describing potential mechanisms that may alter the expression, regulation or function of DAPK.

Address: Section of Experimental Haematology, Division of Cancer Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK. [email protected]

DOI: 10.1111/j.1742-4658.2009.07414.x

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MeSH Terms: Apoptosis Regulatory Proteins, Calcium-Calmodulin-Dependent Protein Kinases, Death-Associated Protein Kinases, Epigenesis, Genetic, Germ-Line Mutation, Humans, Models, Biological, Neoplasms, Polymorphism, Genetic, Protein Processing, Post-Translational, Signal Transduction