Juvenile granulosa cell ovarian tumor: a case report and review of literature.

Sujatha Sivasankaran, Paul Itam, Leslie Ayensu-Coker, Judith Sanchez, Rachel A Egler, Matthew L Anderson, Mary L Brandt, Jennifer E Dietrich

Journal: Journal of pediatric and adolescent gynecology 2009;22(5):e114-7

PMID: 19576820

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

Juvenile granulosa cell tumors (JGCT) are rare ovarian tumors that frequently present with precocious puberty. Presentation in infants less than a year of age is also rare.

CASE

We describe a 10-month-old infant who presented with both premature thelarche and adrenarche due to JGCT. Laboratory evaluation revealed classic elevation of estradiol and inhibin B, and less classic elevation of total and free testosterone. Oophorectomy and staging resulted in a diagnosis of Stage IA JGCT.

SUMMARY AND CONCLUSION

Survival rates are >95% among patients diagnosed under 10 years of age. Tumor recurrence is rare but can occur as late as 48 months. Therefore, tumor surveillance is warranted for patients with even a Stage IA JGCT and involves monitoring serial inhibin B levels along with intermittent imaging.

Address: Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA. [email protected]

DOI: 10.1016/j.jpag.2008.08.001

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MeSH Terms: Adrenarche, Age Determination by Skeleton, Female, Granulosa Cell Tumor, Humans, Immunohistochemistry, Infant, Ovarian Neoplasms, Ovariectomy, Puberty, Precocious, Ultrasonography