Three new compounds from the seeds of L.

Degang Kong, Chuanhou Li, Liang Ding, Zhenhua Tian, Lu Wang, Xue Liu, Qinghe Kong, Honglei Zhou, Lin Liao

Journal: Natural product research 2025;39(9):2398-2404

PMID: 38143317

Abstract

Three undescribed compounds, 1-(4-hydroxyphenyl)-3-((4-hydroxyphenyl)thio) -2-propanone (), 4'-hydroxybenzyl 4-(4''- hydroxybenzyloxy) benzyl thioether () and 3-(4'-hydroxybenzyl)-6-hydroxy-quinazolinone () were isolated from the seeds of L. The structures of all compounds were elucidated based on NMR and MS analysis, along with the comparison with published data. The potential targets of compounds - were identified by virtual screening. The potential inhibitory effects of these compounds on protein kinase C theta type were compared by molecular docking. The docking score of compound was the highest.

Address: College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.; Shandong Medical College, Linyi, China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China.; Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.; First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Department of Endocrinology and Metabology, Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Institute of Nephrology, Jinan, China.; Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Institute of Nephrology, Jinan, China Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational medicine, Shandong Institute of Nephrology, Jinan, China.

DOI: 10.1080/14786419.2023.2297402

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MeSH Terms: Seeds, Molecular Structure, Molecular Docking Simulation, Sinapis, Magnetic Resonance Spectroscopy, Sulfides